This study presents valuable findings by demonstrating that specific GPCR subtypes induce distinct extracellular vesicle miRNA signatures, highlighting a potential novel mechanism for intercellular ...

This study presents a valuable comparison of the efficiency and precision of two prime editing methods to introduce single-nucleotide variants and longer exogenous DNA sequences into the zebrafish ...

The efficiencies with which activated B lymphocytes proliferate and develop into antibody (Ab)- secreting plasma cells are critical determinants of adaptive humoral immunity and central to sustaining ...

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.

The study presents valuable theoretical insights by attempting to classify pattern-forming gene subnetworks and exploring their potential mechanisms. However, the results are incomplete, as they rely ...

During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus ...

Preprints that have been invited for review by eLife are published as Reviewed Preprints and include an eLife assessment, public reviews and a response from the authors (if available).

In this episode, we hear about parasites as molecular matchmakers, drug combinations and cancer treatment, chemical defences in poison frogs, the impact of education on brain structure, and what ...

A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.

A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating ...

The structure of the catalytic core of the N6-methyladenosine RNA methyltransferase complex METTL3-METTL14 reveals that METTL3 is the catalytic subunit, while METTL14 plays non-catalytic roles in ...