For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

The Las Vegas Raiders host the San Francisco 49ers at Allegiant Stadium with kickoff set for 4 p.m. ET on NFL Network, with multiple streaming options available.

The San Francisco 49ers lost starting right guard Dominic Puni and two other offensive players in the first half of their 22-19 preseason win over the Las Vegas Raiders.