The San Francisco 49ers will face the Las Vegas Raiders in week 2 of the NFL preseason on Saturday at Allegiant Stadium.

For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

NFL preseason continues this weekend as the San Francisco 49ers take on the Las Vegas Raiders on Saturday, August 16. Here's everything you need to know.

The San Francisco 49ers and the Las Vegas Raiders face off in Week 2 of the NFL preseason today. Here's where to watch and start time.

Get our expert analysis, picks, and predictions for the Week 2 preseason showdown between the San Francisco 49ers and Las Vegas Raiders

For a moment during Saturday's preseason game against the Las Vegas Raiders, it seemed as if the San Francisco 49ers had turned back the clock with an Owens streaking through the opposing secondary.

The Las Vegas Raiders host the San Francisco 49ers at Allegiant Stadium with kickoff set for 4 p.m. ET on NFL Network, with multiple streaming options available.

Saturday, August 16thTime: 4:00 p.m. ETTV Channel: NFL NetworkLive Stream: fuboTV (watch for free) The San Franci

The Las Vegas Raiders resume Week 2 of the 2025 NFL preseason hosting the San Francisco 49ers today. Where to watch, stream and NFL preseason TV schedule.

Las Vegas Raiders rookie running back Ashton Jeanty ran over a San Francisco 49ers defender in a highlight-reel moment in his second preseason game.