What can you bet in college football? While sportsbooks will offer prop bets on players and game-time situations during the season, those are more difficult to master, particularly if one does not understand the basics. The bread and butter of college football betting consists of the point spread (or "spread"), the total and the moneyline.

The preseason AP Top 25 is expected to confirm what the preseason Coaches poll did a week ago. The first blockbuster matchup of the 2025 college football season should pit No. 1 versus No. 2. Arch Manning and the Texas Longhorns were the top program in the Coaches poll. The Ohio State Buckeyes were right behind them at No. 2.

The numbers of preseason Top 25 teams to finish unranked are trending up each year as college football becomes more unpredictable.